Why the study?
Does moderate or major surgery and anaesthesia accelerate cognitive decline in elderly people?
Population
394 elderly people with median age 72.6 years from the Oxford Project to Investigate Memory and Ageing cohort
Comparison
Moderate or major surgery and anaesthesia vs No moderate or major surgery (implied)
Design
Cohort
Follow-up
median 4.1 (2.0-7.6) years
Authors
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May warrant caution with surgery in elderly with pre-existing impairment; hypothesis-generating and requires randomized confirmation.
Does moderate or major surgery and anaesthesia accelerate cognitive decline in elderly people?
Surgery and anaesthesia accelerate cognitive decline in elderly patients with pre-existing cognitive impairment, but not in those without.
Patel et al. (2016) studied this question.
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