What question did this study set out to answer?

To investigate the role of complement C5 and the membrane attack complex in modulating apoptotic cell death and remyelination during acute and recovery phases of experimental autoimmune encephalomyelitis.

May 1, 2004The Journal of ImmunologyOpen Access

Effects of Complement C5 on Apoptosis in Experimental Autoimmune Encephalomyelitis

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Authors

TNTeodora NiculescuCarol Davila University of Medicine and Pharmacy SWSusanna H. WeerthEunice Kennedy Shriver National Institute of Child Health and Human Development FNFlorin NiculescuUniversity of Maryland, Baltimore

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Implication

Comparative animal study demonstrates that complement C5 reduces oligodendrocyte apoptosis in mice with autoimmune demyelination, suggesting it facilitates central nervous system repair.

Key Points

To investigate the role of complement C5 and the membrane attack complex in modulating apoptotic cell death and remyelination during acute and recovery phases of experimental autoimmune encephalomyelitis.
Induced myelin-directed experimental autoimmune encephalomyelitis in complement C5-deficient (C5-d) and C5-sufficient (C5-s) mice.
Quantified total apoptosis and oligodendrocyte-specific apoptosis using terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) across acute and recovery phases.
Profiled the expression of apoptosis-regulatory genes, including Fas and Fas ligand, using gene arrays and immunostaining.
Total apoptotic cell counts were similar between C5-d and C5-s mice in acute disease, but C5-s mice exhibited significantly fewer apoptotic cells during recovery.
C5-s mice had significantly fewer TUNEL-positive apoptotic oligodendrocytes than C5-d mice during both acute inflammation and recovery phases.
Fas ligand expression was higher in C5-s mice, and while Fas-positive cells were elevated in C5-s mice during acute disease, they declined significantly during recovery.

Cite This Study

Niculescu et al. (2004) studied this question.

synapsesocial.com/papers/6a821752004fcf503374a763 https://doi.org/10.4049/jimmunol.172.9.5702

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Implication

Comparative animal study demonstrates that complement C5 reduces oligodendrocyte apoptosis in mice with autoimmune demyelination, suggesting it facilitates central nervous system repair.

Effects of Complement C5 on Apoptosis in Experimental Autoimmune Encephalomyelitis

Discussion

Member takes

Implication

Key Points

Cite This Study

Effects of Complement C5 on Apoptosis in Experimental Autoimmune Encephalomyelitis

Discussion

Member takes

Implication

Key Points

Cite This Study

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