December 1, 1994Journal of VirologyOpen Access

Distribution of drug resistance mutations in type 3 poliovirus identifies three regions involved in uncoating functions

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Population

Sabin strain of poliovirus type 3 mutants resistant to WIN 51711

Design

Preclinical

Authors

AMAnne G. MosserUniversity of Wisconsin–Madison JSJean-Yves SgroUniversity of Wisconsin–Madison RRRoland R. RueckertUniversity of California, Riverside

Discussion

Member takes

Implication

Warrants targeted antiviral exploration; leaves open translation to human disease or other viruses.

Structured PICO

Population

Sabin strain of poliovirus type 3 mutants resistant to WIN 51711

Intervention

WIN 51711 (uncoating inhibitor)

Outcome

Identification of mutations responsible for drug resistance and dependence

Identifies specific capsid mutations in poliovirus type 3 that confer resistance to or dependence on the uncoating inhibitor WIN 51711, highlighting regions critical for viral uncoating.

Cite This Study

Mosser et al. (1994) studied this question.

synapsesocial.com/papers/6a8218c690702eaf9393ac2c https://doi.org/10.1128/jvi.68.12.8193-8201.1994

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Distribution of drug resistance mutations in type 3 poliovirus identifies three regions involved in uncoating functions

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Distribution of drug resistance mutations in type 3 poliovirus identifies three regions involved in uncoating functions

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider