Why the study?
Does growth hormone replacement improve heart rate variability in adults with growth hormone deficiency?
Population
33 adults including 11 untreated growth hormone deficient patients, 10 GHD patients on long-term GH…
Comparison
Growth hormone replacement for 3 and 6 months. vs Healthy controls and baseline measurements.
Design
Cohort
Follow-up
6 months
Authors
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GH replacement may improve nVLF HRV in GHD; hypothesis-generating and requires randomized confirmation before practice change.
Does growth hormone replacement improve heart rate variability in adults with growth hormone deficiency?
Growth hormone replacement in adults with growth hormone deficiency may partially correct abnormalities in cardiac autonomic tone, as evidenced by early improvements in very low frequency heart rate variability.
Leong et al. (2001) studied this question.
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