Why the study?
Does surgical removal of a left atrial myxoma reduce SAA protein levels in a patient with systemic AA amyloidosis?
Does surgical removal of a left atrial myxoma reduce SAA protein levels in a patient with systemic AA amyloidosis?
This case suggests that atrial myxoma should be added to the list of neoplastic and inflammatory diseases predisposing to AA amyloidosis, as its surgical removal led to the disappearance of the SAA protein precursor.
Answers are grounded in this paper and cite their sources.
Supports atrial myxoma as a rare AA amyloidosis trigger; hypothesis-generating and should not change practice without confirmation.
A 76-year-old woman presenting with generalized amyloidosis of the AA-type protein was found to have a left atrial myxoma. Retrospective estimation of the concentration of SAA protein, a serum precursor of AA amyloid, before and after surgical removal of the myxoma, showed that the SAA protein had disappeared after the operation. A common manifestation of myxoma is the development of a severe inflammatory syndrome that sometimes simulates rheumatic fever or bacterial endocarditis. However, to our knowledge, it has never been described in association with amyloidosis. We suggest that atrial myxoma should be added the list of neoplastic and inflammatory diseases predisposing to AA amyloidosis.
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R. Wens (1989) studied this question.
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