August 1, 1987Circulation
Prevention of ventricular tachycardia induction during right ventricular programmed stimulation by high current strength pacing at the site of origin.
Why the study?
Does high current strength pacing at the site of origin prevent ventricular tachycardia induction during programmed right ventricular stimulation in patients with chronic coronary artery disease?
Population
10 patients with chronic coronary artery disease and 11 inducible ventricular tachycardias.
Comparison
Simultaneous pacing during the 8-beat drive… vs Baseline ventricular tachycardia induction from…
Design
Case_series
Authors
Discussion
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Member takes
Implication
May inhibit VT induction in CAD; hypothesis-generating and requires prospective validation before any clinical role.
Structured PICO
Does high current strength pacing at the site of origin prevent ventricular tachycardia induction during programmed right ventricular stimulation in patients with chronic coronary artery disease?
P
Population
10 patients with chronic coronary artery disease and 11 inducible ventricular tachycardias.
I
Intervention
Simultaneous pacing during the 8-beat drive train from the left ventricular site of origin with high current strength (10 mA or 20 mA) and from the baseline right ventricular site with current strength equal to twice diastolic threshold.
C
Comparator
Baseline ventricular tachycardia induction from the right ventricular apex or outflow tract with a pacing current strength equal to twice diastolic threshold (≤2.0 mA), as well as simultaneous pacing at lower current strength at the site of origin or high current strength at non-sites of origin.
O
Outcome
Prevention of ventricular tachycardia induction.surrogate
High current strength pacing at the site of origin during a drive train can inhibit ventricular tachycardia induction, suggesting a localized electrophysiological effect dependent on pacing site and current strength.
Cite This Study
Marchlinski et al. (1987) studied this question.