Why the study?
Do strategies to achieve early patency improve outcomes in patients with acute myocardial infarction?
Do strategies to achieve early patency improve outcomes in patients with acute myocardial infarction?
Achieving early and sustained patency of the infarct-related artery in acute myocardial infarction is crucial for improving left ventricular function and reducing mortality.
Supports early patency strategies in AMI; leaves open causal confirmation from randomized trials.
The importance of achieving rapid patency of the infarct-related artery during acute myocardial infarction has become well recognized. Early, sustained patency of the infarct-related vessel correlates with improved left ventricular function, better in-hospital outcomes, and lower mortality. Various strategies designed to improve early patency, including "prehospital" thrombolysis, use of an accelerated recombinant tissue plasminogen activator regimen, and immediate angioplasty have been studied. This paper reviews the importance of achieving early patency, the various strategies employed, and the evidence for their efficacy. Future directions in treatment of acute myocardial infarction are touched upon briefly.
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Grover et al. (1995) studied this question.
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