January 1, 1994Circulation
Long-term prognostic importance of patency of the infarct-related coronary artery after thrombolytic therapy for acute myocardial infarction.
Why the study?
Does infarct-related artery patency independently predict long-term prognosis in patients with first myocardial infarction treated with thrombolysis?
Population
312 patients with first myocardial infarction treated < 4 hours after pain onset with thrombolysis
Design
Cohort
Follow-up
39 +/- 13 months
Authors
Discussion
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Member takes
Implication
May refine post-thrombolysis MI risk stratification by EF and patency; leaves open whether targeted interventions improve outcomes.
Structured PICO
Does infarct-related artery patency independently predict long-term prognosis in patients with first myocardial infarction treated with thrombolysis?
P
Population
312 patients with first myocardial infarction treated < 4 hours after pain onset with thrombolysis (streptokinase [n = 188] or recombinant tissue-type plasminogen activator [n = 124])
I
Intervention
Infarct-related artery patency assessed by TIMI scoring and occlusion score at 28 +/- 11 days post-MI
O
Outcome
Long-term prognosis (including cardiac death) at 39 +/- 13 months follow-uphard clinical
Both ventricular function and infarct-related artery patency (measured by occlusion score) are independent long-term prognostic factors after thrombolytic therapy for acute myocardial infarction.
Cite This Study
White et al. (1994) studied this question.