Key result
Complete early reperfusion after MI thrombolysis is linked to ~62% lower in-hospital mortality versus occlusion.
Why the study?
Different thrombolytic regimens for acute myocardial infarction showed equal mortality in large trials despite differences in early infarct-related vessel patency in smaller angiographic studies.
Population
939 acute myocardial infarction patients treated with thrombolysis from four German multicenter studies
Comparison
Complete reperfusion (TIMI grade 3) vs partial reperfusion (TIMI grade 2) vs occluded vessel
Design
Retrospective analysis of four multicenter cohort studies
Follow-up
In-hospital
Authors
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Retrospective analysis reveals early arterial reperfusion reduces short-term mortality after myocardial infarction thrombolysis, indicating the prognostic value of prompt blood flow restoration.
Cohort (n=907)
Yes
Absolute Event Rate: 2.7% vs 7.1%
Vogt et al. (1993) conducted a cohort in Acute myocardial infarction (n=907). Complete early reperfusion (TIMI grade 3) vs. Occluded vessel was evaluated on In-hospital mortality rate. Complete early reperfusion (TIMI grade 3) after thrombolysis for acute myocardial infarction was associated with a lower in-hospital mortality rate (2.7%) compared to an occluded vessel (7.1%).
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