Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
May 1, 2011EuroIntervention

Impact of perfusion restoration at epicardial and tissue levels on markers of myocardial necrosis and clinical outcome of patients with acute myocardial infarction

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does optimal epicardial and tissue perfusion after primary PCI improve myocardial salvage and long-term survival in patients with STEMI?

Population

1,406 patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous…

Comparison

Optimal epicardial and optimal tissue perfusion… vs Optimal epicardial/suboptimal tissue reperfusion…

Design

Cohort

Follow-up

5 years

Authors

GNGjin NdrepepaPAPatricia AlgerMFMassimiliano Fusaro

Discussion

Loading...

Member takes

Overview

Supports combined epicardial and tissue perfusion targets in STEMI PCI; leaves open randomized confirmation before changing practice.

Structured PICO

Does optimal epicardial and tissue perfusion after primary PCI improve myocardial salvage and long-term survival in patients with STEMI?

P
Population
1,406 patients with acute ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI)
I
Intervention
Optimal epicardial and optimal tissue perfusion (TIMI=3/MPG=3) achieved after primary PCI
C
Comparator
Optimal epicardial/suboptimal tissue reperfusion (TIMI=3/MPG ≤ 2) and suboptimal epicardial/suboptimal tissue reperfusion (TIMI ≤ 2/MPG ≤ 2)
O
Outcome
Infarct size assessed by scintigraphy at 7-14 days, frequency of aborted myocardial infarction, and 5-year mortalityhard clinical

Achieving both optimal epicardial and tissue-level perfusion during primary PCI for STEMI significantly reduces infarct size and improves long-term survival.

Cite This Study

Ndrepepa et al. (2011) studied this question.

synapsesocial.com/papers/6a760809b1c5cc4eb2b1d98ehttps://doi.org/10.4244/eijv7i1a21
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Myocardial perfusion grade predicts final infarct size and left ventricular function in patients with ST-elevation myocardial infarction treated with a pharmaco-invasive strategy (thrombolysis and early angioplasty)2015 · 12 citations
  2. 2Myocardial perfusion in ST-elevation myocardial infarction treated successfully with primary angioplasty2006 · 12 citations
  3. 3Reperfusion after primary angioplasty for ST-elevation myocardial infarction: predictors of success and relationship to clinical outcomes in the APEX-AMI Angiographic Study2008 · 57 citations
  4. 4Effects of early myocardial reperfusion and perfusion on myocardial necrosis/dysfunction and inflammation in patients with ST-segment and non-ST-segment elevation acute coronary syndrome: results from the PLATelet inhibition and patients Outcomes (PLATO) trial2022 · 5 citations
  5. 5Impact of Primary Coronary Angioplasty Delay on Myocardial Salvage, Infarct Size, and Microvascular Damage in Patients With ST-Segment Elevation Myocardial Infarction2009 · 285 citations