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March 20, 2008European Heart JournalOpen Access

TIMI myocardial perfusion grade (TMPG) 2/3 after PCI was significantly associated with lower 90-day mortality (adjusted hazard ratio 0.26, 95% CI 0.09-0.78, P = 0.013).

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Why the study?

What are the predictors of successful reperfusion after primary PCI for STEMI, and how does reperfusion success relate to 90-day clinical outcomes?

Population

1018 patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention…

Design

Cohort

Follow-up

90 days

Authors

SBSorin J. BrenerDMDavid J. MoliternoPAPhilip E. Aylward

Discussion

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Member takes

Overview

May aid post-PCI risk stratification in STEMI; leaves open whether perfusion grade is modifiable to improve survival.

Structured PICO

What are the predictors of successful reperfusion after primary PCI for STEMI, and how does reperfusion success relate to 90-day clinical outcomes?

P
Population
1018 patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention (PCI) who underwent independent quantitative angiographic evaluation by a core laboratory (subset of 5745 patients enrolled in the APEX-AMI trial).
I
Intervention
Primary percutaneous coronary intervention (PCI)
O
Outcome
Successful epicardial reperfusion (TIMI flow grade 3 or corrected TIMI frame count <28 frames) and successful myocardial reperfusion (TIMI myocardial perfusion grade 2 or 3), and their association with 90-day mortality and composite of death, congestive heart failure, or shockhard clinical

Successful myocardial perfusion (TMPG 2/3) after primary PCI for STEMI is predicted by younger age, patent infarct-related artery at presentation, and shorter ischemic time, and is associated with improved 90-day survival.

Cite This Study

Brener et al. (2008) studied this question.

synapsesocial.com/papers/6a813cd60fbd199afca8be25https://doi.org/10.1093/eurheartj/ehn125
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