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September 1, 2015EuroIntervention

Myocardial perfusion grade predicts final infarct size and left ventricular function in patients with ST-elevation myocardial infarction treated with a pharmaco-invasive strategy (thrombolysis and early angioplasty)

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Why the study?

Does TIMI myocardial perfusion (TMP) grade at the end of PCI predict LVEF and infarct size at 3 months in STEMI patients treated with thrombolysis and early PCI?

Population

89 patients with ST-elevation myocardial infarction treated with a pharmaco-invasive strategy

Comparison

TIMI myocardial perfusion grade 2-3 at the end… vs TMP grade 0-1

Design

Cohort

Follow-up

3 months

Authors

ABAnne BethkeSHSigrun HalvorsenEBEllen Bøhmer

Discussion

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Overview

TMP grading may aid post-PCI risk stratification in pharmaco-invasive STEMI; leaves open whether it guides therapy or requires prospective validation.

Structured PICO

Does TIMI myocardial perfusion (TMP) grade at the end of PCI predict LVEF and infarct size at 3 months in STEMI patients treated with thrombolysis and early PCI?

P
Population
89 patients with ST-elevation myocardial infarction (STEMI) treated with a pharmaco-invasive strategy (thrombolysis and early percutaneous coronary intervention)
I
Intervention
TIMI myocardial perfusion (TMP) grade 2-3 at the end of the PCI procedure
C
Comparator
TMP grade 0-1 (implied, patients without TMP grade 2-3)
O
Outcome
Left ventricular function (LVEF) and infarct size assessed by MRI after three monthssurrogate

In STEMI patients treated with a pharmaco-invasive strategy, achieving TMP grade 2-3 at the end of PCI is strongly associated with better preserved LVEF and smaller infarct size at 3 months.

Cite This Study

Bethke et al. (2015) studied this question.

synapsesocial.com/papers/6a71359c53da1ffdb507b6echttps://doi.org/10.4244/eijy15m04_02
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