Key result
A history of calcium channel blocker intake was positively associated with achieving open microvasculature (MBG 2/3) in STEMI patients undergoing primary percutaneous coronary intervention.
Why the study?
Do demographic, clinical, and angiographic factors, including prior medication use and admission blood glucose, predict successful angiographic reperfusion in STEMI patients undergoing primary PCI?
Cross-Sectional (n=100)
Single-blind
No
Do demographic, clinical, and angiographic factors, including prior medication use and admission blood glucose, predict successful angiographic reperfusion in STEMI patients undergoing primary PCI?
Answers are grounded in this paper and cite their sources.
Prior use of nitrates and calcium channel blockers, as well as lower admission blood glucose, are associated with better angiographic reperfusion outcomes in STEMI patients undergoing primary PCI.
BACKGROUND: Myocardial blush grade (MBG), thrombolysis in myocardial infarction (TIMI) and corrected TIMI frame count (cTFC) are indices of successful angiographic reperfusion. This study sought to determine the predictors of angiographically successful reperfusion including demographic, clinical and angiographic factors in patients with ST elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI). MATERIALS AND METHODS: A cross-sectional study of patients with a confirmed diagnosis of STEMI undergoing pPCI was designed. Eligible patients referring to a university heart center were enrolled in the study from March 2012 to December 2012. Successful epicardial reperfusion was defned as TIMI flow grade 3 or cTFC<= 28 frames and successful myocardial reperfusion as MBG 2 or 3. RESULTS: The study population consisted of 100 patients, including 74 males and 26 females, with mean ± standard deviation age of 58.27 ± 11.60 years. Achieving open microvasculature (MBG 2/3) was positively associated with a history of nitrate intake (P = 0.03) and history of calcium channel blocker (CCB) intake (P = 0.005). Hyperglycemia was inversely associated with achieving a final cTFC ≤ 28 frames (r = -0.32, P = 0.001). CONCLUSIONS: Our findings suggest that patients with a history of nitrate and CCB intake had a higher likelihood of successful PCI. In addition, patients with a higher blood glucose level on admission may have a reduced rate of reperfusion success. Future studies with a larger sample size are recommended to investigate the significant relationships observed in this study.
No takes yet. Share an insight, caveat, or question.
Talasaz et al. (2014) conducted a cross-sectional in ST elevation myocardial infarction (STEMI) (n=100). History of calcium channel blocker (CCB) intake vs. No history of CCB intake was evaluated on Achieving open microvasculature (MBG 2/3) (r 0.3, p=0.005). A history of calcium channel blocker intake was positively associated with achieving open microvasculature (MBG 2/3) in STEMI patients undergoing primary percutaneous coronary intervention.
Synapse has enriched 10 related papers. Consider them for comparative context: