May 1, 1988Annals of Internal Medicine
Failure of Simple Clinical Measurements to Predict Perfusion Status after Intravenous Thrombolysis
Why the study?
Can simple clinical measurements (ST segment resolution, chest pain resolution, arrhythmias) predict coronary perfusion status early during intravenous thrombolytic therapy in patients with acute myocardial infarction?
Population
386 patients with acute myocardial infarction treated with tissue plasminogen activator
Design
Cohort
Follow-up
90 minutes
Authors
Discussion
Loading...
Member takes
Implication
ST resolution markers lack sensitivity as standalone patency predictors after thrombolysis; leaves open whether multimodal scores improve early noninvasive assessment in AMI.
Structured PICO
Can simple clinical measurements (ST segment resolution, chest pain resolution, arrhythmias) predict coronary perfusion status early during intravenous thrombolytic therapy in patients with acute myocardial infarction?
P
Population
386 patients with acute myocardial infarction treated with tissue plasminogen activator
I
Intervention
Simple clinical measurements (ST segment elevation resolution, chest pain resolution, arrhythmias)
O
Outcome
Coronary patency/perfusion status determined by infarct artery angiography 90 minutes after initiation of therapysurrogate
Simple clinical markers like ST segment or chest pain resolution are highly specific but lack sensitivity for predicting coronary patency after thrombolysis, limiting their clinical utility as standalone predictors.
Cite This Study
Robert M. Califf (1988) studied this question.