Transcription factors. Normal and malignant development of blood cells

Introduction (K. Ravid & J. Licht) Contributors TRANSCRIPTION FACTORS AND THE MEGAKARYOCYTIC AND ERYTHROID LINEAGES The Role of GATA-1 and FOG in Erythroid and Megakaryocytic Differentiation (A. Tsang, et al. ). Regulation of Megakaryocyte and Erythroid Differentiation by NF-E2 (S. -W. Kim & R. Shivdasani) Transcription Factors Involved in Lineage-Specific Gene Expression During Megakaryopoiesis (Y. Kaluzhny, et al. ) Role of TAL1/SCL Transcription Factor in Normal and Leukemic Hematopoiesis (S. Brandt) EKLF and the Development of the Erythroid Lineage (J. Bieker) TRANSCRIPTION FACTORS AND THE MYELOID LINEAGE RUNX1(AML1) and CBFB: Genes Required for the Development of All Definitive Hematopoietic Lineages (N. Speck & E. Dzierzak) PU. 1 and the Development of the Myeloid Lineage (D. Tenen) CCAAT/Enhancer-Binding Proteins in Myeloid Cells (D. -E. Zhang) Homeobox Gene Networks and the Regulation of Hematopoiesis (G. Sauvageau, et al. ) The Role of Retinoic Acid Receptors in Myeloid Differentiation (S. Collins, et al. ) Transcriptional Targets of the Vitamin D 3 Receptor During Myeloid Cell Differentiation (V. Bromleigh, et al. ) TRANSCRIPTION FACTORS AND THE LYMPHOID LINEAGE The Role of Ikaros Family Genes in Lymphopcyte Differentiation and Proliferation (N. Avitahl, et al. ) The Role of PU. 1 in B-Lymphocyte Development and Function (S. Rao & M. Simon) The Role of Pax5 (BSAP) in Early and Late B-Cell Development (M. Horcher, et al. ) Janus Kinases and STAT Family Transcription Factors: Their Role in the Function and Development of Lymphoid Cells (T. Cheng, et al. ) E2A and the Development of B and T Lymphocytes (B. Kee & C. Murre) The Role of BCL-6 in Normal Lymphoid System and non-Hodgkin's Lymphomas (B. Ye) The Role of Octamer Factors and Their Coactivators in the Lymphoid System (E. Bertolino, et al. ) The Role of Early B-Cell Factor in B-Lymphocyte Development (M. Sigvardsson) TRANSCRIPTION FACTORS INVOLVED IN LEUKEMIAS DUE TO CHROMOSOMAL TRANSLOCATION The Role of RARalpha and Its Fusion Partners in Acute Promyelocytic Leukemia (A. Melnick & J. Licht) The Leukemogenic Function of the inv(16) Fusion Gene CBFB-MYH11 (P. Liu, et al. ) EVI1 Rearrangements in Malignant Hematopoiesis (G. Nucifora) t(8 21) AML and the AML1/ETO Fusion Gene: From Clinical Syndrome to Paradigm for the Molecular Basis of Acute Leukemias (R. Frank & S. Nimer) TEL/ETV6 Gene Rearrangements in Human Leukemias (E. Anastasiadou, et al. ) MLL in Normal and Malignant Hematopoiesis (P. Ayton & M. Cleary) Coactivators and Leukemia: The Acetylation Connection with Translocations Involving CBP, p300, TIF2, MOZ, and MLL (V. Chinwalla & N. Zeleznik-Le) The LMO2 Master Gene Its Role as a Transcription Regulator Determining Cell Fate in Leukemogenesis and in Hematopoiesis (Y. Yamada & T. Rabbitts) The Acetyltransferases CBP and p300: Molecular Integrators of Hematopoietic Transcription Involved in Chromosomal Translocations (G. Blobel) ONCOGENESIS AND HEMATOPOIESIS The Roles of the c-myc and b-myb Oncogenes in Hematopoiesis and Leukemogenesis (M. Arsura & G. Sonenshein) NF-kB in Cell Life and Death (W. Tam, et al. ). SUMMARY OF TRANSCRIPTION FACTORS IMPLICATED IN HEMATOPOIESIS: IN VIVO STUDIES Transcription Factors Implicated in Hematopoiesis: In Vivo Studies (Y. Kaluzhny & K. Ravid) Chromosomal Translocations Associated with Disruption of Transcriptional Regulators in Leukemia and Lymphoma (J. Licht) Index.