Why the study?
How does age impact coronary flow reserve and the discordance between FFR and NHPR?
How does age impact coronary flow reserve and the discordance between FFR and NHPR?
Age-related reductions in hyperemic flow decrease CFR and affect FFR but not NHPR, explaining higher rates of physiologic index discordance in older patients.
May contribute to FFR-NHPR discordance in elderly; leaves open whether age-adjusted thresholds refine physiologic assessment.
Key Points CFR decreases with age because hyperemic flow is reduced. Reduced hyperemic flow affects FFR but not NHPR, contributing to a higher rate of discordance between pressure ratios in the elderly. Using a dichotomous age cut off of 60 years, the impact of age in patients with discordant physiologic indices is minimal.
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Morton J. Kern (2022) studied this question.
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