What question did this study set out to answer?

Quantify absolute and relative risks of mental disorders in offspring of parents with schizophrenia, bipolar disorder, or major depressive disorder, assessing whether risk crosses diagnostic boundaries.

August 19, 2013Schizophrenia BulletinOpen Access

Risk of Mental Illness in Offspring of Parents With Schizophrenia, Bipolar Disorder, and Major Depressive Disorder: A Meta-Analysis of Family High-Risk Studies

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Authors

THTomáš HájekDalhousie University MAMartin AldaDalhousie University RURudolf UherUniversity of New Brunswick

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Implication

Meta-analysis reveals elevated psychiatric risk across diagnostic boundaries in offspring of parents with severe mental illness, highlighting broad transdiagnostic vulnerability.

Key Points

Quantify absolute and relative risks of mental disorders in offspring of parents with schizophrenia, bipolar disorder, or major depressive disorder, assessing whether risk crosses diagnostic boundaries.
Meta-analysis of 33 family high-risk studies published through December 2012, encompassing 3,863 offspring of parents with severe mental illness (SMI) and 3,158 control offspring.
Calculated lifetime probability by adulthood (age >20) and pooled risk ratios comparing high-risk offspring to control offspring for parental and non-parental psychiatric disorders.
Offspring of parents with SMI had a 32% probability (95% CI: 24%-42%) of developing SMI by age >20, presenting over double the risk of controls (RR = 2.52; 95% CI: 2.08-3.06, P < .001).
Offspring had elevated risks for their parent's specific disorder (RR = 3.59; 95% CI: 2.57-5.02, P < .001) as well as other severe mental illnesses (RR = 1.92; 95% CI: 1.48-2.49, P < .001).
Parental schizophrenia increased offspring mood disorder risk (RR = 1.62; 95% CI: 1.02-2.58, P = .042), and parental bipolar disorder increased offspring schizophrenia risk (RR = 6.42; 95% CI: 2.20-18.78, P < .001).

Cite This Study

Hájek et al. (2013) studied this question.

synapsesocial.com/papers/6a8223357db08d7cfd3f0fa8 https://doi.org/10.1093/schbul/sbt114

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Implication

Meta-analysis reveals elevated psychiatric risk across diagnostic boundaries in offspring of parents with severe mental illness, highlighting broad transdiagnostic vulnerability.

Risk of Mental Illness in Offspring of Parents With Schizophrenia, Bipolar Disorder, and Major Depressive Disorder: A Meta-Analysis of Family High-Risk Studies

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Key Points

Cite This Study

Risk of Mental Illness in Offspring of Parents With Schizophrenia, Bipolar Disorder, and Major Depressive Disorder: A Meta-Analysis of Family High-Risk Studies

Discussion

Member takes

Implication

Key Points

Cite This Study

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