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What is the role of thrombophilia markers in identifying patients at high risk of venous thromboembolism?
What is the role of thrombophilia markers in identifying patients at high risk of venous thromboembolism?
This review highlights the complex and incompletely understood relationship between thrombophilia markers and the actual clinical risk of developing venous thromboembolism.
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Thrombophilia markers show poor correlation with actual VTE; leaves open their role in risk stratification pending better evidence.
Thrombophilia is defined as a condition predisposing to the development of venous thromboembolic complications. Over the past decades, there have been great advances in the understanding of the pathogenesis of venous thromboembolism (VTE) through the identification of several inherited and acquired risk factors. However, in spite of such progress, a number of questions remain unanswered. In particular, it is well known that some subjects carrying several risk factors for VTE will never experience a thrombotic episode while other individuals developed recurrent thromboembolic events with no known risk factor. In this review, we summarize the current knowledge on the various thrombophilia markers, and also discuss their role in the development of thrombotic complications.
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Mannucci et al. (2014) studied this question.
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