Why the study?
Although inherited thrombophilias can be diagnosed in many patients with VTE, their presence has largely disappointed in informing recurrence risk and anticoagulation duration, leaving the interpretation and clinical application of testing nuanced.
Population
Patients with venous thromboembolism and identified thrombophilic defects
Design
Review with case vignettes
Authors
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Supports de-emphasizing thrombophilia testing in VTE recurrence; leaves open prospective validation before practice change.
Management decisions for VTE in patients with thrombophilias should prioritize individualized assessment of transient risk factors and patient preference over algorithmic pathways based solely on thrombophilia status.
Moran et al. (2020) studied this question.
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