What is the clinical evidence from this study?

Study design: Review. Population: Thrombophilia and venous thromboembolism. Intervention: Thrombophilia testing.

January 1, 2016Journal of Thrombosis and ThrombolysisOpen Access

Guidance for the evaluation and treatment of hereditary and acquired thrombophilia

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Why the study?

Does thrombophilia testing impact clinical management or outcomes in patients with VTE and their relatives?

Population

Patients with venous thromboembolism and their asymptomatic relatives.

Comparison

Thrombophilia testing vs No routine thrombophilia testing

Design

Guideline

Authors

SSScott M. StevensGeneral / Preventive / Lipids SWScott C. WollerVascular Medicine KBKenneth A. BauerBoston University

Discussion

Member takes

Implication

Avoid routine thrombophilia testing after VTE to minimize harm; reinforces selective use only when results alter management.

Structured PICO

Does thrombophilia testing impact clinical management or outcomes in patients with VTE and their relatives?

Population

Clinical guidance document providing recommendations on thrombophilia testing in five clinical situations based on existing guidelines and expert consensus.

Intervention

Thrombophilia testing

Comparator

No routine thrombophilia testing

Outcome

Impact on clinical management (e.g., duration of anticoagulation, primary prophylaxis)

Routine thrombophilia testing is not recommended for most patients with VTE or their relatives, as it does not meaningfully impact clinical management and carries potential risks.

Limitations

Lack of randomized prospective trials testing the utility of thrombophilia testing
Evidence is primarily derived from epidemiologic studies
Guidance relies on consensus expert opinion where formal guidelines are lacking

Cite This Study

Stevens et al. (2016) conducted a review in Thrombophilia and venous thromboembolism. Thrombophilia testing was evaluated. Thrombophilia testing should not be performed in most clinical situations, including after provoked or unprovoked VTE, as it rarely impacts management and may result in patient harm.

synapsesocial.com/papers/6a35358db4dd3b69249ec347 https://doi.org/10.1007/s11239-015-1316-1

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Guidance for the evaluation and treatment of hereditary and acquired thrombophilia

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Guidance for the evaluation and treatment of hereditary and acquired thrombophilia

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider