Thrombophilia Impact on Treatment Decisions, Subsequent Venous or Arterial Thrombosis and Pregnancy-Related Morbidity: A Retrospective Single-Center Cohort Study

Figures

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  Figure 1. Flow diagram of patients.

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  Figure 2. Prevalence of thrombophilia in the cohort. (A) Prevalence of high-risk and low-risk thrombophilia in the cohort. (B) Type of thrombophilia in the cohort. Abbreviations: FVL, factor V Leiden; PT, prothrombin. Testing was not performed or missing for presence of FVL mutation (6%), PT G20210A mutation (13%), antithrombin deficiency (20%), protein C deficiency (30%), protein S deficiency (29%) and antiphospholipid antibody syndrome (11%). Low-risk thrombophilia comprises heterozygous factor V Leiden or heterozygous prothrombin 20210G>A mutation. High-risk thrombophilia comprises homozygous factor V Leiden mutation, homozygous prothrombin 20210G>A mutation, antithrombin < 70%, protein C < 69% and protein S < 59%, antiphospholipid antibody syndrome and compound thrombophilias.

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  Figure 3. Kaplan–Meier survival curves in patients with no thrombophilia, low-risk thrombophilia and high-risk thrombophilia. (A) Patients with subsequent venous thromboembolism. (B) Patients with subsequent arterial thrombosis. (C) Women with subsequent pregnancy-related morbidity. Due to small sample size, a modification of y-axis scale was applied for presentation purposes. Low-risk thrombophilia comprises heterozygous factor V Leiden or heterozygous prothrombin 20210G>A mutation. High-risk thrombophilia comprises homozygous factor V Leiden mutation, homozygous prothrombin 20210G>A mutation, antithrombin < 70%, protein C < 69% and protein S < 59%, antiphospholipid antibody syndrome and compound thrombophilias.