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April 1, 1993European Journal of Clinical Investigation

Apolipoprotein(a) polymorphism predicts the increase of Lp(a) by pravastatin in patients with familial hypercholesterolaemia treated with bile acid sequestration

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Why the study?

Does pravastatin affect Lp(a) concentrations in patients with familial hypercholesterolemia treated with bile acid sequestration?

Population

51 patients with familial hypercholesterolemia or probable FH who had LDL-cholesterol concentration above…

Comparison

Pravastatin vs Placebo

Design

RCT, double-blind

Authors

IKIb Christian KlausenLGLars Ulrik GerdesHMHans Meinertz

Discussion

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Overview

Pravastatin raises Lp(a) in familial hypercholesterolemia; warrants clinical caution and extends evidence of adverse statin effects on Lp(a).

Structured PICO

Does pravastatin affect Lp(a) concentrations in patients with familial hypercholesterolemia treated with bile acid sequestration?

P
Population
51 patients with familial hypercholesterolemia (FH) (n = 43) or probable FH (n = 8) who had LDL-cholesterol concentration above 4.1 mmol/L despite treatment with diet and bile acid sequestration.
I
Intervention
Pravastatin
C
Comparator
Placebo
O
Outcome
Change in Lipoprotein(a) [Lp(a)] concentrationsurrogate

Pravastatin significantly increases Lp(a) levels in patients with familial hypercholesterolemia, with the absolute increase being greatest in patients with low molecular weight apo(a) phenotypes.

Cite This Study

Klausen et al. (1993) studied this question.

synapsesocial.com/papers/6a822826e35fc7ca402a507fhttps://doi.org/10.1111/j.1365-2362.1993.tb00768.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge1972 · 32,626 citations
  2. 2The Mysteries Of Lipoprotein(a)1989 · 1,266 citations
  3. 3Lp(a) phenotyping by immunoblotting with polyclonal and monoclonal antibodies.1988 · 74 citations
  4. 4Helsinki Heart Study: Primary-Prevention Trial with Gemfibrozil in Middle-Aged Men with Dyslipidemia1987 · 3,901 citations
  5. 5Regression of Coronary Artery Disease as a Result of Intensive Lipid-Lowering Therapy in Men with High Levels of Apolipoprotein B1990 · 2,160 citations