Hypercholesterolemia drives progressive aortic valve damage (hypercholesterolemic valvulopathy), with the rate of progression depending on the severity of cholesterol elevation, particularly in familial hypercholesterolemia.
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May support intensified lipid control in familial hypercholesterolemia to slow valve damage; leaves open need for prospective trials to confirm benefit.
Kawaguchi et al. (2003) studied this question.
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