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PURPOSE: To report high-resolution, in vivo imaging of the cornea in a patient with lecithin-cholesterol acyltransferase (LCAT) deficiency. METHODS: A 60-year-old Ecuadorian woman with bilateral corneal opacities and confirmed LCAT deficiency was imaged with Fourier domain optical coherence tomography (FD-OCT) and noncontact Rostock confocal laser scanning microscopy. RESULTS: The FD-OCT revealed a thinned epithelium, homogeneous hyperreflective stroma, and focal disruptions of Bowman's layer. Focal areas of hyperreflectivity with multiple dark striae and reduced and irregular keratocytes were seen throughout the stroma by noncontact Rostock module. The corneal endothelium was normal. CONCLUSION: New anterior segment in vivo imaging technology permits high-resolutional visualization and monitoring of corneal pathology.
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Palmiero et al. (2009) studied this question.
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