What question did this study set out to answer?

To measure and compare pancreatic apparent diffusion coefficient changes after secretin administration to diagnose chronic pancreatitis and assess disease severity.

November 11, 2008Radiology

Assessment of Chronic Pancreatitis: Utility of Diffusion-weighted MR Imaging with Secretin Enhancement

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Authors

MAM. Fatih AkisikIndiana University School of Medicine AAAlex M. AisenPhilips (Finland)KSKumar SandrasegaranMayo Clinic Hospital

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Implication

Retrospective study shows baseline diffusion-weighted MRI measures identify chronic pancreatitis, indicating that secretin stimulation adds limited diagnostic value.

Key Points

To measure and compare pancreatic apparent diffusion coefficient changes after secretin administration to diagnose chronic pancreatitis and assess disease severity.
Retrospectively analyzed 89 patients classified by Cambridge criteria and clinical course as having no chronic pancreatitis (n = 37), mild pancreatitis (n = 33), or severe pancreatitis (n = 19).
Conducted 1.5-T MR cholangiopancreatography with serial diffusion-weighted imaging (b = 0, 100, and 400 sec/mm²) for 10 minutes following secretin injection.
Assessed pairwise ADC group differences using Mann-Whitney tests and determined discriminatory cutoffs via receiver operating characteristic analysis.
Mean nonenhanced and maximum secretin-enhanced ADCs were higher in patients without pancreatitis than in mild or severe chronic pancreatitis, but values did not differ between mild and severe groups.
Percentage increase in ADC and time to peak ADC following secretin injection showed no statistically significant differences across severity groups.
An unenhanced ADC cutoff of less than 179 × 10⁻⁵ mm²/sec provided optimal discrimination between normal pancreas and chronic pancreatitis.

Cite This Study

Akisik et al. (2008) studied this question.

synapsesocial.com/papers/6a822fc3a6fc369586521741 https://doi.org/10.1148/radiol.2493080160

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Implication

Retrospective study shows baseline diffusion-weighted MRI measures identify chronic pancreatitis, indicating that secretin stimulation adds limited diagnostic value.

Assessment of Chronic Pancreatitis: Utility of Diffusion-weighted MR Imaging with Secretin Enhancement

Discussion

Member takes

Implication

Key Points

Cite This Study

Assessment of Chronic Pancreatitis: Utility of Diffusion-weighted MR Imaging with Secretin Enhancement

Discussion

Member takes

Implication

Key Points

Cite This Study

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