Why the study?
Disseminated intravascular coagulation diagnosis relies on clinical and laboratory findings but remains challenging to confirm, especially in early stages.
Are platelet function markers associated with DIC and can they supplement DIC diagnosis?
Population
Patients with DIC across 24 human studies
Comparison
Dynamic platelet function assays or soluble markers vs non-DIC patients and healthy controls
Design
Systematic review
Authors
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May support soluble P-selectin to supplement DIC diagnosis; confirms activation patterns but leaves open standardized clinical use.
Are platelet function markers associated with DIC and can they supplement DIC diagnosis?
Platelet function markers, particularly soluble P-selectin, show potential as supplementary diagnostic tools for DIC, though standardization and adjustment for platelet count are needed.
Hvas et al. (2025) studied this question.
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