Role of Perioperative Administration of 5% Dextrose in Reducing the Incidence of Postoperative Nausea and Vomiting in Laparoscopic Surgeries – A Randomized Control Trial

This is the authors' abstract. We don't add key points for this paper.

Introduction: Postoperative nausea and vomiting (PONV) are one of the major concerns for patients undergoing laparoscopic surgeries.There is conflicting evidence that whether perioperative intravenous dextrose reduces PONV.Objective: To establish the role of dextrose in preventing PONV after laparoscopy.Methods: A prospective double-blind study was conducted with 60 non -diabetic, non-smoker, ASA-I female patients, 18 -60 years of age posted for laparoscopic surgeries (LS) under general anaesthesia (GA).All patients were randomized into 2 groups: Group -D received 5% Dextrose @ 125 ml/hour and Group -N received 0.9% Normal Saline solution@ 125 ml/hour for 2 hours, beginning with the start of surgical closure.PONV scores, hemodynamic parameters, total rescue antiemetic and analgesic consumption were noted in the first 24 hours.Results: Out of 60 patients, Group D, 11(36.7%)patients and Group-N, 19(63.3%)patients need rescue antiemetic.The incidence of PONV was most significant on admission to PACU (p = 0.0388).The overall incidence of PONV was reduced by 26.9% in Group D which was significantly less compared to Group N (P= 0.0029).No statistically significant difference in terms of demographic characteristics, mean duration of surgery, difference of mean capillary blood glucose (CBG) level and requirement of rescue analgesia were noted among 2 groups.Conclusion: Perioperative administration of 5% dextrose reduces the incidence of PONV and consumption of antiemetics in patients undergoing LS under GA.