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Preorganization of the isophthalamide cleft in N, N ‘-dibutyl-4,6-dihydroxyisophthalamide ( 2 ) by means of intramolecular hydrogen bonds results in an enhanced anion receptor that displays significant chloride transport activity into EYPC liposomes. This function is easily switchable by controlling the pH.
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Santacroce et al. (2007) studied this question.
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