Why the study?
Does arterial baroreflex function determine survival time in LPS-induced lethal shock in rats?
Population
Rats divided into four groups
Comparison
Intravenous lipopolysaccharide (LPS) 50 mg/kg vs Comparison between groups with different…
Design
Preclinical
Follow-up
Until death (up to approximately 150 minutes)
Authors
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Baroreflex sensitivity may determine survival in rodent endotoxemia; leaves open relevance to human septic shock.
Does arterial baroreflex function determine survival time in LPS-induced lethal shock in rats?
Arterial baroreflex function is a key determinant of survival time in a rat model of LPS-induced lethal shock.
Shen et al. (2004) studied this question.
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