Key result
Sino-aortic denervation worsens LV dP/dt by ~25% during endotoxin-induced hypotension.
Why the study?
The role of arterial baroreceptors in the cardiovascular response to hypotension induced by E. coli endotoxin was unclear.
Does arterial baroreceptor buffering capacity affect cardiovascular responses to E. coli endotoxin-induced hypotension in anesthetized dogs?
Population
Anesthetized dogs
Comparison
Sino-aortic denervation vs intact baroreceptors prior to E. coli endotoxin injection
Design
Preclinical experimental study
Follow-up
60 minutes
Authors
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Animal model of endotoxin shock shows hemodynamic instability; leaves open baroreceptor buffering role in clinical sepsis.
Does arterial baroreceptor buffering capacity affect cardiovascular responses to E. coli endotoxin-induced hypotension in anesthetized dogs?
Absolute Event Rate: 2340% vs 3138%
p-value: p=<0.05
Arterial baroreceptors may play a role in the poor compensatory response to endotoxin-induced hypotension, specifically regarding stroke volume and left ventricular dP/dt.
Koyama et al. (1986) studied Endotoxic hypotension (n=20). Sino-aortic denervation vs. Sham operation was evaluated on Left ventricular dP/dt at 60 minutes post-endotoxin injection (p=<0.05). Sino-aortic denervation in dogs resulted in significantly greater decreases in stroke volume and left ventricular dP/dt during E. coli endotoxin-induced hypotension compared to sham-operated controls.
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