Finding AT tracts: High selectivity for long AT sequences can be attained through kinetically controlled DNA threading intercalation by binuclear ruthenium(II) complexes (see picture). The rate of intercalation is strongly correlated to the number of consecutive AT base pairs and is up to 2500-times higher with poly(dAdT)2 than with mixed-sequence DNA.
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Nordell et al. (2007) studied this question.
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