What question did this study set out to answer?

To assess the effects of cardiopulmonary bypass surgery and two distinct levels of intraoperative hypothermia on whole-body protein turnover and skeletal muscle breakdown.

January 1, 1991AJP Endocrinology and Metabolism

Effect of surgical injury and intraoperative hypothermia on whole body protein metabolism

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To assess the effects of cardiopulmonary bypass surgery and two distinct levels of intraoperative hypothermia on whole-body protein turnover and skeletal muscle breakdown.
Randomized trial in 20 male patients undergoing cardiac surgery with cardiopulmonary bypass, assigned to an intraoperative blood temperature of either 28°C or 20°C.
Whole body protein synthesis (WBPS) and breakdown (WBPB) were assessed before and after surgery using a primed 24-hour [15N]glycine infusion, measuring 15N enrichment in urinary urea, ammonium, and end-product average (EPA), alongside urinary nitrogen and 3-methyl-L-histidine (3-MH) excretion.
Median urinary nitrogen excretion increased by 40% in the 28°C group (P < 0.03) and 22% in the 20°C group (P = 0.10); median 3-MH excretion rose postoperatively by 79% in the 28°C group (P = 0.01) and 66% in the 20°C group (P < 0.01).
Postoperative WBPS derived from urinary urea fell by 23% in the 28°C group (P < 0.01) and 11% in the 20°C group (P = NS), whereas WBPS derived from urinary ammonium increased by 20% at 28°C (P = NS) and 29% at 20°C (P = 0.03).
End-product average calculations showed no statistically significant postoperative changes in overall WBPS or WBPB in either temperature group.

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Implication

Randomized trial reveals muscle protein breakdown and altered protein synthesis across hypothermic regimens in cardiac surgery patients, suggesting deeper hypothermia may attenuate nitrogen loss.

Cite This Study

Taggart et al. (1991) studied this question.

synapsesocial.com/papers/6a8244cbf07048b4a7ac95c9 https://doi.org/10.1152/ajpendo.1991.260.1.e118

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Implication

Randomized trial reveals muscle protein breakdown and altered protein synthesis across hypothermic regimens in cardiac surgery patients, suggesting deeper hypothermia may attenuate nitrogen loss.

Effect of surgical injury and intraoperative hypothermia on whole body protein metabolism

Key Points

Discussion

Implication

Cite This Study

Effect of surgical injury and intraoperative hypothermia on whole body protein metabolism

Key Points

Discussion

Implication

Cite This Study

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