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High-dose cytarabine can cause symptomatic sinus bradycardia, documented as a definite adverse drug reaction using the Naranjo Scale.
Cardiac complications of high-dose cytosine arabinoside (HiDAC), although rare, predominantly include pericarditis, pericardial effusion and cardiomyopathy (with concurrent use of cyclophosphamide). Clinically significant arrhythmias associated with HiDAC, although reported in the literature, are rare. The following case report has for the first time used the Naranjo Scale to document a high-probability association (definite adverse drug reaction) of cytarabine with symptomatic sinus bradycardia.
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Wayangankar et al. (2010) studied this question.
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