Open sesame: The proteasome complex is a nanodegradation machine that is essential for cellular protein turnover. A multivalent chelator head (MCH) was exploited for the specific binding to histidine-tagged proteasomes, even in crude cell lysates. Acting as synthetic gatekeepers, this MCH controls the access and thus the proteolytic activity of the nanomachinery.
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Schulze et al. (2006) studied this question.
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