Why the study?
Atrial fibrillation is common and worsens outcomes in patients undergoing TMVR for severe mitral regurgitation, but data on the impact of AF treatment strategy in this cohort are unknown.
Does rhythm control therapy improve survival compared to rate control therapy in patients with atrial fibrillation undergoing transcatheter mitral valve repair?
Does rhythm control therapy improve survival compared to rate control therapy in patients with atrial fibrillation undergoing transcatheter mitral valve repair?
In patients undergoing TMVR, pharmacological rhythm control for concomitant atrial fibrillation is associated with worse long-term survival compared to rate control, potentially driven by adverse effects of amiodarone.
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May favor rate over rhythm control with amiodarone in TMVR patients with AF; leaves open need for RCTs to confirm association.
Waechter et al. (2021) studied this question.
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