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June 4, 2021Heart

Real-world utilisation of angiotensin-neprilysin inhibitors in older adults with heart failure

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Why the study?

Following guideline incorporation of ARNI after PARADIGM-HF, the real-world utilisation of ARNI in older adults with HFrEF warranted evaluation.

Population

HFrEF patients age ≥65 years from the Medicare database (2014–2017)

Comparison

ARNI vs ACEi/ARB in initiator and switcher subcohorts

Design

Retrospective Medicare database analysis

Authors

JGJan M. GriffinRCRichard K. Cheng

Discussion

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Overview

Informs targeted efforts to boost ARNI uptake in older HFrEF patients; leaves open optimal implementation strategies.

Structured PICO

P
Population
HFrEF patients age ≥65 years from the Medicare database (2014–2017)
I
Intervention
Angiotensin receptor-neprilysin inhibitor (ARNI)
C
Comparator
ACE inhibitors (ACEi) or angiotensin receptor blockers (ARB)

This editorial discusses a real-world analysis of ARNI utilization among older adults with HFrEF in the US Medicare system.

Limitations

  • potential misclassification of HF based on ICD codes

Cite This Study

Griffin et al. (2021) studied this question.

synapsesocial.com/papers/6a8249141fb4be735b3f12bahttps://doi.org/10.1136/heartjnl-2021-319545
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin receptor/neprilysin inhibitor—a breakthrough in chronic heart failure therapy: summary of subanalysis on PARADIGM-HF trial findings2019 · 23 citations
  2. 2ARNI in HFrEF—One-Centre Experience in the Era before the 2021 ESC HF Recommendations2022 · 2 citations
  3. 3Angiotensin Receptor Neprilysin Inhibitor for Patients With Heart Failure and Reduced Ejection Fraction: Real-World Experience From Taiwan2019 · 28 citations
  4. 4Effectiveness of angiotensin-neprilysin inhibitor treatment versus renin-angiotensin system blockade in older adults with heart failure in clinical care2021 · 23 citations
  5. 5Use and Benefit of Sacubitril/Valsartan in Elderly Patients with Heart Failure with Reduced Ejection Fraction2024 · 6 citations