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February 17, 2017Catheterization and Cardiovascular Interventions

End‐stage renal disease and severe aortic stenosis: Does valve replacement improve one‐year outcomes?

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Why the study?

Does valve replacement (TAVR or SAVR) improve 1-year survival compared to balloon aortic valvuloplasty in patients with end-stage renal disease and severe aortic stenosis?

Population

85 patients with end-stage renal disease (ESRD) and severe aortic stenosis (AS)

Comparison

Transcatheter aortic valve replacement or… vs Balloon aortic valvuloplasty (BAV) only

Design

Cohort

Follow-up

1 year

Authors

JCJosé F. CondadoAMAneel MainiBLBradley G. Leshnower

Discussion

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Overview

Valve replacement associated with lower 1-year mortality than BAV in ESRD with severe AS; leaves open need for randomized confirmation.

Structured PICO

Does valve replacement (TAVR or SAVR) improve 1-year survival compared to balloon aortic valvuloplasty in patients with end-stage renal disease and severe aortic stenosis?

P
Population
85 patients with end-stage renal disease (ESRD) and severe aortic stenosis (AS)
I
Intervention
Transcatheter aortic valve replacement (TAVR) or surgical aortic valve replacement (SAVR)
C
Comparator
Balloon aortic valvuloplasty (BAV) only
O
Outcome
1-year mortalityhard clinical

In patients with end-stage renal disease and severe aortic stenosis, definitive valve replacement (TAVR or SAVR) is associated with significantly higher 1-year survival compared to balloon aortic valvuloplasty alone.

Cite This Study

Condado et al. (2017) studied this question.

synapsesocial.com/papers/6a824960f2e4e6540e2a5454https://doi.org/10.1002/ccd.26875
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Balloon Aortic Valvuloplasty in 170 Consecutive Patients1988 · 234 citations
  2. 2Transcatheter Aortic-Valve Implantation for Aortic Stenosis in Patients Who Cannot Undergo Surgery2010 · 7,243 citations
  3. 3Updated standardized endpoint definitions for transcatheter aortic valve implantation: the Valve Academic Research Consortium-2 consensus document†2012 · 1,054 citations