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March 4, 2016Catheterization and Cardiovascular InterventionsOpen Access

The outcomes of transcatheter aortic valve replacement in a cohort of patients with end‐stage renal disease

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Why the study?

Does transcatheter aortic valve replacement improve survival and reduce complications in patients with end-stage renal disease and aortic stenosis?

Population

43 patients with end-stage renal disease and aortic stenosis, mean age 76.2 ± 11.0 years, mean STS predicted…

Design

Cohort

Follow-up

6 months

Authors

MSMolly SzerlipRKRebeca J. KimTATokunbo Adeniyi

Discussion

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Overview

High mortality after TAVR in ESRD warrants caution in patient selection; leaves open whether benefits exceed risks versus medical therapy.

Structured PICO

Does transcatheter aortic valve replacement improve survival and reduce complications in patients with end-stage renal disease and aortic stenosis?

P
Population
43 patients with end-stage renal disease (ESRD) and aortic stenosis, mean age 76.2 ± 11.0 years, mean STS predicted risk of mortality 15.53 ± 8.70%, mean duration of dialysis 45.2 ± 52.3 months.
I
Intervention
Transcatheter aortic valve replacement (TAVR) via transfemoral (72.1%), transapical (25.6%), or transaortic (2.3%) approach.
O
Outcome
Operative mortality and 6-month mortalityhard clinical

TAVR in patients with end-stage renal disease carries high mortality and complication risks, though the transfemoral approach appears to have lower operative mortality compared to non-transfemoral approaches.

Cite This Study

Szerlip et al. (2016) studied this question.

synapsesocial.com/papers/6a824960f2e4e6540e2a5455https://doi.org/10.1002/ccd.26347
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Transapical aortic valve replacement in extreme-risk patients: outcome, risk factors and mid-term results2012 · 15 citations
  2. 2Transcatheter Aortic Valve Replacement Using a Self-Expanding Bioprosthesis in Patients With Severe Aortic Stenosis at Extreme Risk for Surgery2014 · 1,049 citations
  3. 3Transcatheter Aortic-Valve Implantation for Aortic Stenosis in Patients Who Cannot Undergo Surgery2010 · 7,243 citations
  4. 4Transcatheter Aortic-Valve Replacement with a Self-Expanding Prosthesis2014 · 2,919 citations
  5. 5Paravalvular Aortic Leak After Transcatheter Aortic Valve Replacement2013 · 215 citations