Irradiation as an Etiologic Factor in the Development of Melanoma

In certain cases, the relationship of irradiation as an etiologic factor in the production of melanoma was dramatic and unquestioned, with a relatively short interval between application of irradiation and appearance of melanoma. The effect was a rather prompt, massive breakdown of local immunity factors and precipitation of melanoma in the precise area of port of irradiation. In other instances, causal relationship was implied and the time interval more protracted. Irradiation factors were not completely available but instrumentation was conventional equipment, doses relatively small, and application superficial. Effects appeared to be related to superficial melanoma clinically in all instances but one. Long-range outlook is reflected in the fact that only one individual has survived over ten years.