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Summary: A simplified method for the assay of serum vitamin B 12 by isotopedilution is described. Results obtained by this method correlated well with those obtained by microbiological assay using Lactobacillus leichmannii ; reproducibility was of the same order and the range of values obtained in normal subjects fell within the accepted range. There was no difficulty in detecting clinical vitamin B 12 deficiency.
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Britt et al. (1969) studied this question.
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