December 1, 1996The Journal of Clinical Endocrinology & MetabolismOpen Access

Genetic variation in P450c11AS in Chilean patients with low renin hypertension.

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Population

Patients from a single clinic in Santiago, Chile, including an initial cohort of 12 patients with low renin…

Design

Case-control

Authors

CFCarlos FardellaPontificia Universidad Católica de Chile HRHenry RodriguezUniversity of South Florida JMJavier MonteroIVI Valencia Clinic

Discussion

Member takes

Implication

Arg173 variant associated with hypertension in Chileans; hypothesis-generating and requires replication before any clinical consideration.

Structured PICO

Population

Patients from a single clinic in Santiago, Chile, including an initial cohort of 12 patients with low renin hypertension (LRH), 2 high renin hypertensive controls, and 2 normotensive controls, followed by a larger cohort of 52 unselected patients with idiopathic hypertension and 55 normotensive controls.

Comparator

Normotensive controls

Outcome

Frequency of the Arg173 variant of the CYP11B2 genesurrogate

The Arg173 variant of the CYP11B2 gene is more frequent in hypertensive patients and may be linked to low renin hypertension in the Chilean population.

Cite This Study

Fardella et al. (1996) studied this question.

synapsesocial.com/papers/6a8253200ebbaf848246c5ef https://doi.org/10.1210/jcem.81.12.8954040

Topics

Hypertension management

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Implication

Arg173 variant associated with hypertension in Chileans; hypothesis-generating and requires replication before any clinical consideration.

Genetic variation in P450c11AS in Chilean patients with low renin hypertension.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Genetic variation in P450c11AS in Chilean patients with low renin hypertension.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider