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Review emerging non-resorptive functions of osteoclasts and their precursors in bone homeostasis, hematopoiesis, and immune regulation.

January 1, 2009Critical Reviews in Eukaryotic Gene ExpressionOpen Access

Osteoclasts Have Multiple Roles in Bone in Addition to Bone Resorption

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Review emerging non-resorptive functions of osteoclasts and their precursors in bone homeostasis, hematopoiesis, and immune regulation.
Synthesized findings from recent literature detailing the differentiation, migration, and non-resorptive signaling behavior of myeloid-derived osteoclast precursors.
Evaluated cellular interactions between osteoclasts, osteoblasts, hematopoietic stem cells, and immune mediators across physiological and pathological microenvironments.
Osteoclasts and their precursors directly modulate osteoblast precursor differentiation and facilitate the mobilization of hematopoietic stem cells from bone marrow into the bloodstream.
Osteoclasts actively participate in immune responses and secrete functional cytokines that regulate both inflammatory and neoplastic processes within the skeletal microenvironment.

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Implication

Scientific review reveals diverse non-resorptive signaling and immune functions of osteoclasts in skeletal tissue, highlighting novel therapeutic targets in osteoimmunology.

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Boyce et al. (2009) studied this question.

synapsesocial.com/papers/6a8255aa44e83484cc93ba1a https://doi.org/10.1615/critreveukargeneexpr.v19.i3.10

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Implication

Scientific review reveals diverse non-resorptive signaling and immune functions of osteoclasts in skeletal tissue, highlighting novel therapeutic targets in osteoimmunology.

Osteoclasts Have Multiple Roles in Bone in Addition to Bone Resorption

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Discussion

Implication

Cite This Study

Osteoclasts Have Multiple Roles in Bone in Addition to Bone Resorption

Key Points

Discussion

Implication

Cite This Study

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