Starting from α-bromovinylarenes, propargyl bromides, and dienophiles, a novel intermolecular tandem Pd-catalyzed cross-coupling/[4+4] and [4+2] cycloaddition sequence provides bicyclo[6.4.0]dodecane derivatives by a rapid synthesis in one reaction vessel. Five components are assembled into one molecule in this process. EWG=electron-withdrawing group.
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Lee et al. (2005) studied this question.
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