Synthetic study demonstrates the assembly of nine-membered carbocycles using a palladium catalyst, indicating an unprecedented pathway distinct from rhodium-mediated cycloadditions.
A palladium catalyst serves as a template for the assembly of a nine-membered carbocycle from two molecules of vinylallene and one molecule of carbon monoxide [Eq. (a)]. This unprecedented [4+4+1] cycloaddition is in marked contrast to the [4+1] cycloaddition mediated by rhodium(I) catalysts.
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Murakami et al. (1998) studied this question.
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