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April 1, 1994Journal of the American Chemical Society

Catalytic version of the Intramolecular Pauson-Khand Reaction

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Authors

NJNakcheol JeongYeouido St. Mary's HospitalSHSung Hee HwangUC Davis Comprehensive Cancer CenterYLYoung‐Shin LeeKyung Hee University Medical Center

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Implication

Experimental study demonstrates catalytic intramolecular Pauson-Khand cyclization of enynes, indicating an atom-economical route to cyclopentenones.

Key Points

  • Develop a catalytic variant of the intramolecular Pauson-Khand reaction to overcome the requirement for stoichiometric transition metal reagents.
  • Examined transition metal catalyst systems for promoting the intramolecular cycloaddition of enynes with carbon monoxide.
  • Screened catalytic reaction conditions to facilitate intramolecular coupling into bicyclic frameworks.
  • Demonstrated catalytic turnover for the intramolecular transformation of enyne substrates into cyclopentenones.
  • Achieved ring formation without the consumption of stoichiometric metal complexes, improving the atom economy of the cyclization.

Cite This Study

Jeong et al. (1994) studied this question.

synapsesocial.com/papers/6a8256e3aedbb2834ec6adf3https://doi.org/10.1021/ja00086a070
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