UV inactivation of RNA-directed DNA polymerase activity in Rauscher leukemia virus is due to protein damage, requiring 2.4-3.1 x 10^4 ergs/mm^2 for 37% survival.
Supports protein damage as UV target in murine retroviral polymerase; leaves open applicability to human pathogens or disinfection protocols.
The UV inactivation of RNA-directed DNA polymerase activity of Rauscher leukemia virus was shown to be due to damage to the protein. The UV dose resulting in 37% survival of viral polymerase activity at 254 nm was 2.4 x 10(4) to 3.1 x 10(4) ergs/mm(2). The inactivation rate of p30, a major internal viral protein, was much slower.
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Lovinger et al. (1975) studied this question.
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