A NUMBER of studies have established the presence of lysosomes in the tubular and interstitial cells of the rat kidney.1 2 3 4 5 6 Because they contain several proteolytic enzymes lysosomes are thought to function in normal intracellular digestion.7 However, some experimental evidence suggests that disruption of their surrounding membrane in vivo may result in tissue damage or destruction.7 Because of the possibility that lysosomes are present in the human kidney and may be involved in certain kinds of renal disease, it was thought to be of interest to measure urinary beta-glucuronidase (an enzyme concentrated in rat-kidney lysosomes2) in normal subjects and patients . . .
No takes yet. Share an insight, caveat, or question.
Bank et al. (1965) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: