Why the study?
Does purified host DNA-suppressing factor (DSF) inhibit cellular DNA synthesis in synchronized HeLa cell cultures?
Does purified host DNA-suppressing factor (DSF) inhibit cellular DNA synthesis in synchronized HeLa cell cultures?
DSF irreversibly inhibits cellular DNA synthesis in HeLa cells when introduced during the early G1-phase.
Purified host DNA-suppressing factor (DSF) produced into culture fluid of HeLa C-9 cells infected with measles virus inhibited cellular DNA synthesis in HeLa cells. When purified DSF was added into cultures of synchronous HeLa cells at the early G1-phase, cellular DNA synthesis was irreversibly inhibited. However, DSF did not affect the stability of native double-stranded DNA nor the chain-elongation of single-stranded DNA in cells of the S-phase.
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Minagawa et al. (1977) studied this question.
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