Population
Macrophages (parental RAW 264.7 cells and RES cells resistant to endogenously generated NO)
Comparison
Exogenous NO donors with or without MEK… vs Parental RAW 264.7 cells or untreated cells
Design
Preclinical
Authors
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Raises caution for exogenous NO donor effects in resistant macrophages; leaves open MEK inhibition as a therapeutic target pending human studies.
Macrophages resistant to endogenous NO undergo hypersensitive, caspase 3-independent apoptosis when exposed to exogenous NO donors, a process reversible by MEK inhibition.
Mohr et al. (1998) studied this question.
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