Why the study?
Human enteroviruses cause severe neurological complications and possess various mechanisms to suppress the host type I interferon response to establish replication.
Enteroviral RdRP acts as an antagonist to the host antiviral response by inhibiting MDA5-mediated beta interferon activation.
Identifies enteroviral RdRP as MDA5 antagonist in animal models; leaves open its role in human disease and therapeutic targeting.
Infection by enteroviruses causes severe neurological complications in humans. Human enteroviruses possess various mechanisms to suppress the host type I interferon (IFN) response in infected cells to establish viral replication. In the present study, we found that the enteroviral 3D pol protein (or RdRP), which is a viral RNA-dependent RNA polymerase for replicating viral RNA, plays a role in the inhibition of MDA5-mediated beta interferon (IFN-β) promoter activation. We further demonstrated that enteroviral 3D pol protein interacts with the caspase activation and recruitment domains (CARDs) of MDA5. These findings indicate that enteroviral RdRP functions as an antagonist against the host antiviral response.
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Kuo et al. (2019) studied this question.
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